Hsp is usually selflimiting in 94% of children and 89% of adults. The patient had experienced multiple hospitalizations in the prior 12 months and had demonstrated chronic kidney disease, with a serum creatinine level in the 2. Henochschonlein purpura hsp is a vasculitis inflammation of blood vessels that affects small blood vessels mainly in the skin, intestines, and kidneys. Henochschonlein purpura also known as iga vasculitis is a disorder that causes the small blood vessels in your skin, joints, intestines, and kidneys to become inflamed and bleed. Although hsp is typically a disease of children, adult cases have been described.
To describe the incidence of hospital admission among children in the scottish population for henochschonlein purpura hsp. This guideline has been adapted for statewide use with the support of the victorian paediatric clinical network. Emna bahloul 1, makram koubaa 2, frikha fatma1, masmoudi abderrahmen 1, mseddi madiha 1, hend chaabane 1, mounir ben jmeaa 2, hamida turki 1 1department of dermatology, hedi chaker university hospital, sfax, tunisia 2department of infectious diseases, hedi chaker university hospital, sfax, tunisia. Henochschonlein purpura hsp is an immunologically mediated disease associating purpura plus urticaria, characteristically affecting lower limbs, buttocks, and elbows. A 65yearold man presented with a 1week history of abdominal pain and was noted to have acute kidney failure, with a serum creatinine level of 3. Severe hemorrhagic bullous lesions in henoch schonlein purpura. The iga deposits in vessel walls, associated with the. Dec 10, 2018 henoch schonlein purpura hsp, also called immunoglobulin a vasculitis igav, is a vascular disease that primarily affects small blood vessels. The disease is characterized by abnormal deposits of immunoglobulin a an antibody in the blood vessels, leading to their inflammation vasculitis. The inflammation causes blood vessels in the skin, intestines. Henochschonlein purpura, childhood polyarteritis nodosa, childhood wegener granulomatosis and childhood takayasu arteritis. Henochschoenlein purpura is a leukocytoclastic vasculitis of childhood characterized by abdominal pain, bloody diarrhea, petechiae, and potential risk of renal involvement.
The most striking feature of this form of vasculitis is a purplish rash, typically on the lower legs and buttocks. Hsp can affect multiple organs with a characteristic rash present in all patients. The small vessels of the skin, joints, kidneys, and digestive organs are particularly involved. Neurologic manifestations of schoenleinhenoch purpura. Henochschonlein purpura hsp is the most frequent vasculitis in. Henochschonlein purpura vasculitis revealing human immunodeficiency virus infection. Started in 1995, this collection now contains 6769 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. Henoch schonlein purpura hsp is a disease involving inflammation of small blood vessels.
Henoch schonlein purpura, nephritis, therapy, children introduction henoch schonlein purpura hsp is an immunologically mediated disease associating purpura plus urticaria, characteristically affecting lower limbs, buttocks, and elbows. Most cases resolve with symptomatic treatment, but serious complications can occur such as renal failure. A rash in henochschonlein purpura is not always the presenting manifestation and as hakim has stated, the rash may not be typical. The primary symptom is a rash that looks like many small raised bruises. Symptoms can begin in children, most commonly between the ages of 4 and 7 years, soon after an upper respiratory tract infection or a streptococcalpharyngitis sore throat infection. If the skin rash in henochschonlein purpura hsp is atypical, a skin biopsy should be done to look for the classic leukocytoclastic vasculitis. It affects children, mainly males, in 90% of cases the four main clinical features include purpura rash, abdominal pain, arthralgia and renal involvement. The diagnosis and classification of henochschonlein purpura. Urinalysis is the only investigation required in a classic presentation of hsp. Jul 24, 2019 henoch schonlein purpura also known as iga vasculitis is a disorder that causes the small blood vessels in your skin, joints, intestines, and kidneys to become inflamed and bleed. Henochschonlein purpura symptoms and causes mayo clinic. Endoscopy of the small bowel shows ulcerous hemorrhagic enteritis, together with a wide range of elementary lesions.
If such an examination was done, it was not reported by the authors. Clinical course of extrarenal symptoms in henochschonlein purpura. Henochschonlein purpura allergy and clinical immunology. This article is part of an expert video encyclopedia. Henochschonlein purpura with abdominal involvement. Hsp can also affect the kidneys, digestive tract, and joints. Further investigations may be required if the diagnosis is unclear, abdominal symptoms. Henochschonlein purpura hsp, also called immunoglobulin a vasculitis igav, is a vascular disease that primarily affects small blood vessels.
Children may develop arthritis inflammation of the. The role of corticosteroid in hemorrhagic bullous henoch schonlein purpura. A 7 12 yearold boy was seen with status epilepticus after a 2week history of generalized headaches, irritability, and intermittent colicky abdominal pain. Analysis of the literature indicates the importance of genetic and infectious aetiologic considerations in the development of hsp.
Frequently, hsp leads to abdominal pain and intestinal bleeding, renal involvement and joint pain. Clinical course of extrarenal symptoms in henoch schonlein purpura. Should children with henochschonlein purpura and abdominal pain be treated with steroids. Purpura occurs in all patients but is the presenting complaint in only 75% of cases significant abdominal and renal complications can occur and need exclusion pulmonary and neurological involvement are both rare but may be lifethreatening if present. Henochschonlein purpura hsp is an autoimmune, multisystem, acute vasculitis of childhood commonly involving the skin, gut, joints and the kidneys. Three patients developed prominent neurologic symptoms and signs associated with schoenleinhenoch purpura. An epidemiological study of henochschonlein purpura. Therapy for children with henochschonlein purpura nephritis. Henochschonlein purpura vasculitis revealing human.